PAR-4 (1-6) amide (mouse)
Catalog No:CP-PARP-014B
Manufacturer:CPC Scientific
Size:25 mg
CAS No.:245443-52-1
Formula:C33H46N 8O7
MWt:667
€323,00
Product Name: | PAR-4 (1-6) amide (mouse) |
Category: | Peptides |
Three letter sequence: | H-Gly-Tyr- Pro-Gly-Lys- Phe-NH2 Trifluoroacet ate salt |
One letter sequence: | GYPGKF-NH2 |
Description: | Protease-activated receptor-4 activating peptide derived from murine PAR-4. This peptide was able to cause rat platelet aggregation with an EC50 value of 40 碌 M. Its effect on leucocyte rolling and adherence points at a role of PAR-4 in mediating proinflammatory processes. The family of at least seven transmembrane G protein coupled receptors includes at least four receptor subtypes (PAR1, PAR2, PAR3, PAR4). PAR4 activating peptides, GYPGKF-NH2 and AYPGKG-NH2, |
Literature References: | N.Vergnolle, J. Immunol., 163, 5064 (1999) M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001) Ref: Fang, J. et al. Blood 106, 2671(2005) Mul猫, F. et al. Gut. 53, 229 (2004) Sekiguchi, F. et al. Drug Design Rev. 1, 287 (2004) Faruqi, T. et al. J. Biol. Chem. 275, 19728 (2000) Greenberg, D. Biochem. 42, 2702 (2003) Henriksen, R. and V. Hanks, Arterioscler. Thromb. Vasc. Biol. 22, 861 |
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