PAR-3 (1-6) amide (human)
Catalog No:CP-PARP-008A
Manufacturer:CPC Scientific
Size:5 mg
Formula:C29H46N 10O7
MWt:647
€150,00
Product Name: | PAR-3 (1-6) amide (human) |
Category: | Peptides |
Three letter sequence: | Thr-Phe-Arg- Gly-Ala-Pro- NH2 Trifluoroacet ate salt |
One letter sequence: | TFRGAP-NH2 |
Description: | This peptide is a human PAR-3- derived tethered ligand, which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR- expressing cells. PAR3 Tethered Ligand (Human) / Activates PAR1 and PAR2 This peptide is the 1- 6 fragment of the protease-activated receptor 3 (PAR-3), which induces ERK activation in human carcinoma cells endogeneously expressing PAR1 and PAR3. This effect is completely abolished by single alanine substitution |
Literature References: | K.K.Hansen et al., Immunology, 112, 183 (2004) Kaufmann, R. et al. Regul. Pept. 125, 61( 2005) McLaughlin, J. et al. PNAS 104, 5662 (2007) Arisato, T. et al. Cell. Mol. Life Sci. 60, 1420 (2003) |
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