Orexin A, human
Catalog No:CP-OREX-001A
Manufacturer:CPC Scientific
Size:0.5 mg
Formula:C152H243 N47044S4
MWt:3,561
€297,00
Product Name: | Orexin A, human |
Category: | Peptides |
Three letter sequence: | Glp-Pro-Leu- Pro-Asp-Cys- Cys-Arg-Gln- Lys-Thr-Cys- Ser-Cys-Arg- Leu-Tyr-Glu- Leu-Leu-His- Gly-Ala-Gly- Asn-His-Ala- Ala-Gly-Ile- Leu-Thr-Leu- NH2(Cys6&C ys12 bridge , Cys7&Cys14 bridge) |
One letter sequence: | Glp- PLPDCCRQKT CSCRLYELLHG AGNHAAGILTL- NH2(C6&C12 bridge , C7&C14 bridge) |
Description: | Hypothalamic neuropeptide that regulates feeding behavior and significantly augments food intake in a dose- dependent manner when a bolus is administered intracerebroventricul arly. After a 48-hour fast, hypothalamic prpro-orexin mRNA level is up-regulated 2.4. The discovery of orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis. |
Literature References: | M.W. Schwartz, Nature Med ., 4, 385 (1998); T. Sakurai et al., Cell , 92, 573 (1998) |
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