opeptide W-30 (rat)
Catalog No:CP-NEUP-015B
Manufacturer:CPC Scientific
Size:1 mg
CAS No.:383415-90-5
Formula:C165H249 N49O38S
MWt:3,559
€253,00
Product Name: | opeptide W-30 (rat) |
Category: | Peptides |
Three letter sequence: | Trp-Tyr-Lys- His-Val-Ala- Ser-Pro-Arg- Tyr-His-Thr- Val-Gly-Arg- Ala-Ser-Gly- Leu-Leu-Met- Gly-Leu-Arg- Arg-Ser-Pro- Tyr-Leu-Trp Trifluoroacet ate salt |
One letter sequence: | WYKHVASPRY HTVGRASGLL MGLRRSPYLW |
Description: | This peptide was recently identified as the endogenous ligand for the two structurally related orphan G-protein- coupled receptors (GPCRs) GPR7 and GPR8 which are expressed in the central nervous system. NPW-30 activated and bound to both GPR7 and GPR8 at similar effective doses. Intracerebroventricul ar administration of NPW in rats resulted in an increased food intake and stimulation of prolactin release indicating that NPW acts as a mediator of the central control of feeding and the |
Literature References: | al., J. Biol. Chem., 277, 35826 (2002) S.Brezillon et al., J. Biol. Chem., 278, 776 (2003) H.Tanaka et al., Proc. Natl. Acad. Sci. USA, 100, 6251 (2003) Y. Shimomura et al., J. Biol. Chem., 277, 35826 (2002) S. Brezillon et al., J. Biol. Chem., 278, 776 (2003) H. Tanaka et al., Proc. Natl. Acad. Sci. USA,100, 6251 (2003) M.S. Mondal et al., Endocrinology, 144, 4729 (2003) F. Takenoya et al., Regul. Pept., 145, 159 (2008) |
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