Non-Aβ Component of Alzheimer's Disease Amyloid
Catalog No:CP-AMYD-052A
Manufacturer:CPC Scientific
Size:0.5 mg
CAS No.:154040-19-4
Formula:C141H235 N39O49
MWt:3,261
€356,00
Product Name: | Non-A尾 Component of Alzheimer’s Disease Amyloid |
Category: | Peptides |
Three letter sequence: | Glu-Gln-Val- Thr-Asn-Val- Gly-Gly-Ala- Val-Val-Thr- Gly-Val-Thr- Ala-Val-Ala- Gln-Lys-Thr- Val-Glu-Gly- Ala-Gly-Ser- Ile-Ala-Ala- Ala-Thr-Gly- Phe-Val Trifluoroacet ate salt |
One letter sequence: | EQVTNVGGAV VTGVTAVAQKT VEGAGSIAAAT GFV |
Description: | This peptide was isolated from the insoluble core of Alzheimer’s disease (AD) amyloid plaque. It is the fragment (61-95) of NACP or 伪 -synuclein and forms amyloid fibrils via a nucleation- dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases. |
Literature References: | H.Han et al., Chemistry and Biology, 2, 163 (1995) A.Iwai et al., Biochemistry, 34, 10139 (1995 |
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