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Western blot analysis of extracts of various cell lines, using NLRP2 antibody (A8233) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
NLRP2 Rabbit pAb
Catalog No：AB-A8233
Manufacturer：ABclonal
Synonyms：NLRP2;CLR19.9;NALP2;NBS1;PAN1;PYPAF2
Applications：WB,IF
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | NLRP2 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human NLRP2 (NP_060322.1). |
| Gene ID: | 55655 |
| Swiss prot: | Q9NX02 |
| Molecular weight: | 96kDa/117kDa/118kDa/120kDa |
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