Neuropeptide EI-Gly-Arg-Arg- MCH (human, mouse, rat)
Catalog No:CP-MCH-003B
Manufacturer:CPC Scientific
Size:1 mg
Formula:C182H282 N54O52S 4
MWt:4,187
€819,00
Product Name: | Neuropeptide EI-Gly-Arg-Arg- MCH (human, mouse, rat) |
Category: | Peptides |
Three letter sequence: | Glu-Ile-Gly- Asp-Glu-Glu- Asn-Ser-Ala- Lys-Phe-Pro- Ile-Gly-Arg- Arg-Asp-Phe- Asp-Met-Leu- Arg-Cys-Met- Leu-Gly-Arg- Val-Tyr-Arg- Pro-Cys-Trp- Gln-Val (Disulfide bond) Trifluoroacet ate salt |
One letter sequence: | EIGDEENSAKF PIGRRDFDMLR CMLGRVYRPC WQV |
Description: | Neuropeptide EI-Gly- Arg-Arg-MCH (human, mouse, rat) has been shown to be more potent in stimulating feeding in the rat than MCH following intracerebroventricul ar administration although it did not exhibit better agonist activity in in vitro assays. Its enhanced activity in feeding behaviour compared to MCH might be due to its reduced susceptibility to proteolytic degradation by MCH- degrading enzymes such as endopeptidase 24.11 and aminopeptidase M. |
Literature References: | A.Viale et al., J. Biol. Chem., 274, 6536 (1999) L.Maulon-Feraille et al., J. Pharmacol. Exp. Ther., 302, 766 (2002) |
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