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Immunohistochemistry of paraffin-embedded mouse lung using MUC16 antibody (A10005) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human liver damage using MUC16 antibody (A10005) at dilution of 1:100 (40x lens).
MUC16 Rabbit pAb
Catalog No：AB-A10005
Manufacturer：ABclonal
Synonyms：MUC16;CA125;mucin-16
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | MUC16 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 13965-14064 of human MUC16 (NP_078966.2). |
| Gene ID: | 94025 |
| Swiss prot: | Q8WXI7 |
| Molecular weight: | 1519kDa |
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