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Western blot analysis of extracts of various cell lines, using MSR1 antibody (A14187) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
MSR1 Rabbit pAb
Catalog No：AB-A14187
Manufacturer：ABclonal
Synonyms：MSR1;CD204;SCARA1;SR-A;SR-AI;SR-AII;SR-AIII;SRA;phSR1;phSR2
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | MSR1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer’s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 192-451 of human MSR1 (NP_619729.1). |
| Gene ID: | 4481 |
| Swiss prot: | P21757 |
| Molecular weight: | 39kDa/42kDa/49kDa |
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