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Western blot analysis of extracts of C6 cells, using MonoMethyl-UHRF1-K385 antibody (A16008) at 1:1000 dilution.C6 cells were treated by MG132(50 μM) at 37℃ for 90 minutes.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
MonoMethyl-UHRF1-K385 Rabbit pAb
Catalog No：AB-A16008
Manufacturer：ABclonal
Synonyms：UHRF1;ICBP90;Np95;RNF106;TDRD22;hNP95;hUHRF1;huNp95
Applications：DB,WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | MonoMethyl-UHRF1-K385 Rabbit pAb |
| Category: | Methylated Antibodies |
| Description: | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. |
| Immunogen: | A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1). |
| Gene ID: | 29128 |
| Swiss prot: | Q96T88 |
| Molecular weight: | 89kDa/91kDa |
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