MED12 Rabbit pAb
Catalog No:AB-A18302
Manufacturer:ABclonal
Synonyms:MED12;ARC240;CAGH45;FGS1;HOPA;MED12S;OHDOX;OKS;OPA1;TNRC11;TRAP230
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €325,00
Product Name: | MED12 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. |
Immunogen: | Recombinant protein of human MED12. |
Gene ID: | 9968 |
Swiss prot: | Q93074 |
Molecular weight: | 243kDa |
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