Western blot analysis of extracts of various cell lines, using MC1 Receptor antibody (A13512) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 15s.
MC1 Receptor Rabbit pAb
Catalog No:AB-A13512
Manufacturer:ABclonal
Synonyms:MC1R;CMM5;MSH-R;SHEP2
Applications:WB
Reactivity:Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | MC1 Receptor Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human MC1 Receptor (NP_002377.4). |
Gene ID: | 4157 |
Swiss prot: | Q01726 |
Molecular weight: | 34kDa |
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