Western blot analysis of extracts of various cell lines, using Mast Cell Tryptase (Mast Cell Tryptase (TPSB2)) antibody (A15887) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
Mast Cell Tryptase (TPSB2) Rabbit pAb
Catalog No:AB-A15887
Manufacturer:ABclonal
Synonyms:TPSB2;TPS2;tryptaseB;tryptaseC
Applications:WB
Reactivity:Human,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | Mast Cell Tryptase (TPSB2) Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3′ UTR and contain tandem repeat sequences at the 5′ flank and 3′ UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human Mast Cell Tryptase (Mast Cell Tryptase (TPSB2)) (NP_077078.5). |
Gene ID: | 64499 |
Swiss prot: | P20231 |
Molecular weight: | 30kDa |
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