Western blot analysis of extracts of HeLa cells, using MASP1 antibody (A5693) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
MASP1 Rabbit pAb
Catalog No:AB-A5693
Manufacturer:ABclonal
Synonyms:MASP1;3MC1;CRARF;CRARF1;MAP1;MASP;MASP3;MAp44;PRSS5;RaRF
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | MASP1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human MASP1 (NP_001870.3). |
Gene ID: | 5648 |
Swiss prot: | P48740 |
Molecular weight: | 43kDa/68kDa/79kDa/81kDa |
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