[Lys(Ac)373]- p53 (368-393), p53 K373(Ac), biotin-labeled, human
Catalog No:CP-CANC-003A
Manufacturer:CPC Scientific
Size:0.25 mg
MWt:3,610
€146,00
Product Name: | [Lys(Ac)373]- p53 (368-393), p53 K373(Ac), biotin-labeled, human |
Category: | Peptides |
Three letter sequence: | Biotin-Lys- Gly-Trp-His- Leu-Lys-Ser- Lys-Lys(Ac)- Gly-Gln-Ser- Thr-Ser-Arg- His-Lys-Lys- Leu-Met- Phe-Lys-Thr- Glu-Gly-Pro- Asp-Ser-Asp- NH2 |
One letter sequence: | Biotin- KGWHLKSK- K(Ac)- GQSTSRHKKL MFKTEGPDSD- NH2 |
Description: | This is a biotin- labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with acetylation at Lys373 and additional KGW residues on its N- terminus. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo. |
Literature References: | Kubbutat, M. et al. Lett Nature 387, 299 (1997) Li, M. et al. J Biol Chem 277, 50607 (2002). |
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