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Western blot analysis of extracts of various cell lines, using LDLR antibody (A14996) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 30s.
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Immunohistochemistry of paraffin-embedded Mouse lung using LDLR antibody (A14996) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded Rat kidney using LDLR antibody (A14996) at dilution of 1:100 (40x lens).
LDLR Rabbit pAb
Catalog No：AB-A14996
Manufacturer：ABclonal
Synonyms：LDLR;FH;FHC;LDLCQ2
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | LDLR Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human LDLR (NP_000518.1). |
| Gene ID: | 3949 |
| Swiss prot: | P01130 |
| Molecular weight: | 75kDa/76kDa/82kDa/90kDa/95kDa |
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