KRIT1 Rabbit pAb
Catalog No：AB-A16356
Manufacturer：ABclonal
Synonyms：KRIT1;CAM;CCM1
Applications：IHC
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €325,00
| Product Name: | KRIT1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 467-736 of human KRIT1 (NP_919438.1). |
| Gene ID: | 889 |
| Swiss prot: | O00522 |
| Molecular weight: | 60kDa/78kDa/84kDa |
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