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Western blot analysis of extracts from normal (control) and STIM1 knockout (KO) HeLa cells, using STIM1 antibody (A19894) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
[KO Validated] STIM1 Rabbit pAb
Catalog No：AB-A19894
Manufacturer：ABclonal
Synonyms：STIM1;D11S4896E;GOK;IMD10;STRMK;TAM;TAM1
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | [KO Validated] STIM1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3′ end of this gene situated 1.6 kb from the 5′ end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. |
| Immunogen: | Recombinant protein of human STIM1. |
| Gene ID: | 6786 |
| Swiss prot: | Q13586 |
| Molecular weight: | 62kDa/77kDa |
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