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Western blot analysis of extracts of various cell lines, using Lamin A/C Rabbit pAb (A17319).|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|
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Western blot analysis of extracts from normal (control) and Lamin A/C Rabbit pAb knockout (KO) HeLa cells, using Lamin A/C Rabbit pAb antibody (A17319).|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|
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Immunohistochemistry of paraffin-embedded human stomach using Lamin A/C antibody (A17319) at dilution of 1:200 (40x lens).
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Immunohistochemistry of paraffin-embedded rat brain using Lamin A/C antibody (A17319) at dilution of 1:200 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse brain using Lamin A/C antibody (A17319) at dilution of 1:200 (40x lens).
[KO Validated] Lamin A/C Rabbit pAb
Catalog No：AB-A17319
Manufacturer：ABclonal
Synonyms：LMNA;CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;LDP1;LFP;LGMD1B;LMN1;LMNC;LMNL1;MADA;PRO1;lamin;Lamin A/C
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | [KO Validated] Lamin A/C Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. |
| Immunogen: | A synthetic peptide of human Lamin A/C |
| Gene ID: | 4000 |
| Swiss prot: | P02545 |
| Molecular weight: | 62-74kDa |
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