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Western blot analysis of extracts from normal (control) and FADD knockout (KO) HeLa cells, using FADD antibody (A18082) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
[KO Validated] FADD Rabbit pAb
Catalog No：AB-A18082
Manufacturer：ABclonal
Synonyms：GIG3;MORT1;FADD;FADD
Applications：WB,IHC,IP
Reactivity：Human,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | [KO Validated] FADD Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1). |
| Gene ID: | 8772 |
| Swiss prot: | Q13158 |
| Molecular weight: | 23kDa |
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