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Western blot analysis of extracts of NCI-H460 cells, using KCNN3 antibody (A6125) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 60s.
KCNN3 Rabbit pAb
Catalog No：AB-A6125
Manufacturer：ABclonal
Synonyms：KCNN3;KCa2.3;SK3;SKCA3;hSK3
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | KCNN3 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 237-426 of human KCNN3 (NP_740752.1). |
| Gene ID: | 3782 |
| Swiss prot: | Q9UGI6 |
| Molecular weight: | 47kDa/48kDa/82kDa |
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