Intermedin (rat)
Catalog No:CP-HITM-002A
Manufacturer:CPC Scientific
Size:0.5 mg
Formula:C226H361 N75O64S 2
MWt:5,217
€285,00
Product Name: | Intermedin (rat) |
Category: | Peptides |
Three letter sequence: | Pro-His-Ala- Gln-Leu-Leu- Arg-Val-Gly- Cys-Val-Leu- Gly-Thr-Cys- Gln-Val-Gln- Asn-Leu-Ser- His-Arg-Leu- Trp-Gln-Leu- Val-Arg-Pro- Ser-Gly-Arg- Arg-Asp-Ser- Ala-Pro-Val- Asp-Pro-Ser- Ser-Pro-His- Ser-Tyr-NH2 (Disulfide bond Cys10- Cys15) Trifluoroacet ate salt |
One letter sequence: | PHAQLLRVGCV LGTCQVQNLS HRLWQLVRPS GRRDSAPVDP SSPHSY-NH2 |
Description: | Intermedins are members of the calcitonin/CGRP family. In vitro studies have shown that the synthetic 47 amino acid intermedin peptides act through the calcitonin receptor- like receptor/receptor activity-modifying protein (CRLR/RAMP) complexes by increasing intracellular cAMP levels. Unlike calcitonin gene- related peptide (CGRP) and adrenomedullin (ADM) intermedin exhibited no preference for one of the three RAMPs when co-expressed |
Literature References: | Y.Fujisawa et al., Am. J. Physiol. Heart Circ. Physiol., 290, H1120 (2006) M.Chauhan et al., Endocrinology, 148, 1727 (2007) M. Ogoshi et al.,Biochem. Biophys. Res. Commun., 311, 1072 (2003). Y. Takei et al.,FEBS Lett., 556, 53 (2004). J. Roh et al., J. Biol. Chem., 279, 7264 (2004) Y. Fujisawa et al., Eur. J. Pharmacol., 497, 75 (2004). M.M. Taylor et al.,Integr. Comp. Physiol., 288, R919 (2005). |
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