Insulin B (9 - 23)
Catalog No:CP-PANP-008A
Manufacturer:CPC Scientific
Size:1 mg
Formula:C72H116 N20O22S
MWt:1,646
€94,00
Product Name: | Insulin B (9 – 23) |
Category: | Peptides |
Three letter sequence: | Ser-His-Leu- Val-Glu-Ala- Leu-Tyr-Leu- Val-Cys-Gly- Glu-Arg-Gly |
One letter sequence: | SHLVEALYLVC GERG |
Description: | This insulin B-chain peptide binds to a MHC-II allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin- dependent diabetes mellitus, is a T cell- mediated disease that results in autoimmune destruction of pancreatic 脽 cells leading to hyperglycemia. This insulin B peptide may be a self- antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies |
Literature References: | Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005). |
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