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Western blot analysis of extracts of HepG2 cells, using HSD11B2 antibody (A8077) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 15s.
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Immunohistochemistry of paraffin-embedded rat kidney using HSD11B2 antibody (A8077) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human liver damage using HSD11B2 antibody (A8077) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human stomach using HSD11B2 antibody (A8077) at dilution of 1:100 (40x lens).
HSD11B2 Rabbit pAb
Catalog No：AB-A8077
Manufacturer：ABclonal
Synonyms：HSD11B2;AME;AME1;HSD11K;HSD2;SDR9C3
Applications：WB,IHC
Reactivity：Human,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | HSD11B2 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 266-405 of human HSD11B2 (NP_000187.3). |
| Gene ID: | 3291 |
| Swiss prot: | P80365 |
| Molecular weight: | 44kDa |
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