.jpg)
Western blot analysis of extracts of various cell lines, using HMGCR antibody (A16875) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
.jpg)
Immunohistochemistry of paraffin-embedded human colon using HMGCR antibody (A16875) at dilution of 1:200 (40x lens).
HMGCR Rabbit pAb
Catalog No：AB-A16875
Manufacturer：ABclonal
Synonyms：HMGCR;LDLCQ3;HMGCR
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | HMGCR Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Immunogen: | Recombinant protein of human HMGCR. |
| Gene ID: | 3156 |
| Swiss prot: | P04035 |
| Molecular weight: | 92kDa/97kDa/99kDa |
Help & Support
Product
Guarantee and
Expert Support
Related products
Catalog No：AB-A0094
Manufacturer：ABclonal
Synonyms：CDKN2, p33(CDK2)
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
Catalog No：AB-A0068
Manufacturer：ABclonal
Synonyms：BCR;ALL;BCR1;CML;D22S11;D22S662;PHL
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0058
Manufacturer：ABclonal
Synonyms：FLT;FLT-1;VEGFR-1;VEGFR1;FLT1
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0054
Manufacturer：ABclonal
Synonyms：AGM7;GRB1;IMD36;p85;p85-ALPHA;PI3 Kinase p85 alpha;PIK3R1
Applications：WB,IHC
Reactivity：Human,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0024
Manufacturer：ABclonal
Synonyms：FADK;FAK;FAK1;FRNK;PPP1R71;p125FAK;pp125FAK;PTK2
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €295,00
Catalog No：AB-A0027
Manufacturer：ABclonal
Synonyms：CANDF7;IMD31A;IMD31B;IMD31C;ISGF-3;STAT91;STAT1 alpha;STAT1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00