HEXB Rabbit pAb
Catalog No:AB-A1916
Manufacturer:ABclonal
Synonyms:ENC-1AS;HEL-248;HEL-S-111;HEXB
Applications:IF
Reactivity:Mouse
Host:Rabbit
Conjugate:No
€65,00 – €325,00
Product Name: | HEXB Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 277-556 of human HEXB (NP_000512.1). |
Gene ID: | 3074 |
Swiss prot: | P07686 |
Molecular weight: | 63kDa |
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