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Western blot analysis of extracts of various cell lines, using GRM8 antibody (A2964) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.
GRM8 Rabbit pAb
Catalog No：AB-A2964
Manufacturer：ABclonal
Synonyms：GRM8;GLUR8;GPRC1H;MGLUR8;mGlu8
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | GRM8 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Immunogen: | A synthetic peptide of human GRM8 |
| Gene ID: | 2918 |
| Swiss prot: | O00222 |
| Molecular weight: | 55kDa/101kDa |
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