Western blot analysis of extracts of various cell lines, using GALR2 antibody (A17577) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 2min.
GALR2 Rabbit pAb
Catalog No:AB-A17577
Manufacturer:ABclonal
Synonyms:GAL2-R;GALNR2;GALR-2;GALR2
Applications:WB
Reactivity:Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | GALR2 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008] |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GALR2 (NP_003848.1). |
Gene ID: | 8811 |
Swiss prot: | O43603 |
Molecular weight: |
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