Western blot analysis of extracts of various cell lines, using FLT3 antibody (A12462) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
FLT3 Rabbit pAb
Catalog No:AB-A12462
Manufacturer:ABclonal
Synonyms:FLT3;CD135;FLK-2;FLK2;STK1
Applications:WB
Reactivity:Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | FLT3 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 650-750 of human FLT3 (NP_004110.2). |
Gene ID: | 2322 |
Swiss prot: | P36888 |
Molecular weight: | 108kDa/112kDa |
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