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Western blot analysis of extracts of HepG2 cells, using FGL1 antibody (A20335) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
FGL1 Rabbit mAb
Catalog No：AB-A20335
Manufacturer：ABclonal
Synonyms：FGL1;HFREP1;HP-041;LFIRE-1;LFIRE1
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | FGL1 Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. The FGL1-LAG-3 pathway maybe an important immune evasion mechanism and could contribute to current cancer immunotherapy efforts for several reasons. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy |
| Immunogen: | Recombinant protein of human FGL-1 Full length. |
| Gene ID: | 2267 |
| Swiss prot: | Q08830 |
| Molecular weight: | 36kDa |
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