Western blot analysis of extracts of various cell lines, using FADD antibody (A16459) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
FADD Rabbit pAb
Catalog No:AB-A16459
Manufacturer:ABclonal
Synonyms:GIG3;MORT1;FADD;FADD
Applications:WB,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | FADD Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
Immunogen: | Recombinant protein of human FADD |
Gene ID: | 8772 |
Swiss prot: | Q13158 |
Molecular weight: | 23kDa |
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