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Western blot analysis of extracts of various cell lines, using FADD antibody (A19049) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
FADD Rabbit mAb
Catalog No：AB-A19049
Manufacturer：ABclonal
Synonyms：GIG3;MORT1;FADD;FADD
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | FADD Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] |
| Immunogen: | A synthesized peptide derived from human FADD |
| Gene ID: | 8772 |
| Swiss prot: | Q13158 |
| Molecular weight: | 28kDa |
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