Gemfibrozil [Cas No. 25812-30-0]
Catalog No:TA-T1415
Manufacturer:TargetMol
Synonyms:CI-719,Lopid,Jezil,Decrelip
CAS No.:25812-30-0
Formula:C15H22O3
MWt:250.33
€20,00 – €70,00
Name: | Gemfibrozil |
Category: | Biochemicals |
Description: | Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). |
Pathway: | Metabolism,GPCR/G Protein, DNA Damage/DNA Repair |
Target: | PPAR agonist,P450,Adrenergic Receptor |
Receptor: | PPARα,CYP2C9,1A2 |
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