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Western blot analysis of extracts of rat brain, using ErbB4/HER4 antibody (A0749) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
ErbB4/HER4 Rabbit pAb
Catalog No：AB-A0749
Manufacturer：ABclonal
Synonyms：ALS19;HER4;p180erbB4;ERBB4;HER4/ErbB4
Applications：WB,IF
Reactivity：Human,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | ErbB4/HER4 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human ErbB4/HER4 (NP_005226.1). |
| Gene ID: | 2066 |
| Swiss prot: | Q15303 |
| Molecular weight: | 143kDa/145kDa/146kDa |
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