Enfuvirtide
Catalog No:CP-ENFU-001B
Manufacturer:CPC Scientific
Size:5 mg
CAS No.:159519-65-0
Formula:C204H301 N51O64
MWt:4,492
€600,00
Product Name: | Enfuvirtide |
Category: | Peptides |
Three letter sequence: | Ac-Tyr-Thr- Ser-Leu-Ile- His-Ser-Leu- Ile-Glu-Glu- Ser-Gln-Asn- Gln-Gln-Glu- Lys-Asn-Glu- Gln-Glu-Leu- Leu-Glu-Leu- Asp-Lys-Trp- Ala-Ser-Leu- Trp-Asn-Trp- Phe-NH2 |
One letter sequence: | Ac- YTSLIHSLIEES QNQQEKNEQE LLELDKWASL WNWF-NH2 |
Description: | HIV binds to the host CD4+ cell receptor via the viral protein gp120; gp41. Enfuvirtide binds to gp41 preventing the conformational changes in gp41 which is necessary for fusion of the virus with the cell. |
Literature References: | H.B.Fung and Y.Guo, Clin. Ther., 26, 352 (2004) R.Manfredi and S.Sabbatani, Curr. Med. Chem., 13, 2369 (2006) J.Ruof et al., Clin. Drug Investig., 27, 469 (2007) A.Streinu-Cercel et al., HIV Clin. Trials, 9, 375 (2008) |
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