Entrectinib [Cas No. 1108743-60-7]
Catalog No：TA-T3678
Manufacturer：TargetMol
Synonyms：RXDX-101,NMS-E628
CAS No.：1108743-60-7
Formula：C31H34F2N6O2
MWt：560.64
€42,00 – €329,00
| Name: | Entrectinib |
| Category: | Biochemicals |
| Description: | Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK, IC50: 1.6 nM) and C-ros oncogene 1 (ROS1, IC50: 0.2 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with C1156Y or L1196M resistance mutations, and inhibits ALK‐dependent signaling. It has been shown to inhibit the growth of a non-small cell lung Y cell line bearing an EML4-ALK rearrangement. In mice bearing various ROS1, Trk, or ALK-driven xenografts, Entrectinib has been shown to induce tumor regression. |
| Pathway: | Angiogenesis, Immunology & Inflammation, Tyrosine Kinase/Adaptors |
| Target: | ALK inhibitor, ROS inhibitor, Trk receptor inhibitor |
| Receptor: | ALK, ROS1, TrkA, TrkB, TrkC |
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