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Western blot analysis of extracts of HeLa cells, using DUSP6 antibody (A0637).|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.
DUSP6 Rabbit pAb
Catalog No：AB-A0637
Manufacturer：ABclonal
Synonyms：DUSP6;HH19;MKP3;PYST1
Applications：WB,IF
Reactivity：Human
Host：Rabbit
Conjugate：No
€245,00 – €370,00
| Product Name: | DUSP6 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. |
| Immunogen: | A synthetic peptide of human DUSP6 |
| Gene ID: | 1848 |
| Swiss prot: | Q16828 |
| Molecular weight: | 26kDa/42kDa |
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