Western blot analysis of extracts of Mouse heart, using DROSHA Rabbit pAb (A8336) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 180s.
DROSHA Rabbit pAb
Catalog No:AB-A8336
Manufacturer:ABclonal
Synonyms:DROSHA;ETOHI2;HSA242976;RANSE3L;RN3;RNASE3L;RNASEN
Applications:WB,IF
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | DROSHA Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DROSHA (NP_037367.3). |
Gene ID: | 29102 |
Swiss prot: | Q9NRR4 |
Molecular weight: | 138kDa/151kDa/155kDa/159kDa |
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