DNA polymerase eta Rabbit pAb
Catalog No:AB-A1833
Manufacturer:ABclonal
Synonyms:POLH;RAD30;RAD30A;XP-V;XPV
Applications:WB,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | DNA polymerase eta Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human DNA polymerase eta (NP_006493.1). |
Gene ID: | 5429 |
Swiss prot: | Q9Y253 |
Molecular weight: | 46kDa/78kDa |
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