Bractoppin [Cas No. 2290527-07-8]
Catalog No：TA-T8873
Manufacturer：TargetMol
CAS No.：2290527-07-8
Formula：C25H23FN4O
MWt：414.47
€55,00 – €897,00
| Name: | Bractoppin |
| Category: | Biochemicals |
| Description: | Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity. |
| Pathway: | Others |
| Target: | Others |
| Receptor: | Others |
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