Western blot analysis of extracts of Mouse brain, using DCC antibody (A9372) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 300s.
DCC Rabbit pAb
Catalog No:AB-A9372
Manufacturer:ABclonal
Synonyms:DCC;CRC18;CRCR1;IGDCC1;MRMV1;NTN1R1
Applications:WB
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€125,00 – €370,00
Product Name: | DCC Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. |
Immunogen: | A synthetic peptide of human DCC |
Gene ID: | 1630 |
Swiss prot: | P43146 |
Molecular weight: | 158kDa |
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