DABCYL-TNF- a-EDANS (-4to +6), human
Catalog No:CP-SUBS-014A
Manufacturer:CPC Scientific
Size:0.5 mg
Formula:C70H104 N22O18S 1
MWt:1,574
€89,00
Product Name: | DABCYL-TNF- a-EDANS (-4 to +6), human |
Category: | Peptides |
Three letter sequence: | DABCYL- Leu-Ala-Gln- Ala-Val-Arg- Ser-Ser-Ser- Arg-EDANS |
One letter sequence: | Dabcyl- LAQAVRSSSR- Edans |
Description: | TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF- convertase. |
Literature References: | A.J. H.Gearing et al., Nature , 370, 555 (1994) K.M. Mohler et al., Nature , 370, 218 (1994) Becker BF, et al.Biol Chem 383, 1821-6 (2002) Mohler KM, et al., Nature 370, 218- 20. (1994) |
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