CRK/CRKII Rabbit pAb
Catalog No:AB-A1604
Manufacturer:ABclonal
Synonyms:CRK;CRKII;p38
Applications:WB,IHC
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | CRK/CRKII Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human CRK/CRKII (NP_058431.2). |
Gene ID: | 1398 |
Swiss prot: | P46108 |
Molecular weight: | 22kDa/33kDa |
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