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Western blot analysis of extracts of NIH/3T3 cells, using CREBBP antibody (A1334) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 180s.
CREBBP Rabbit pAb
Catalog No：AB-A1334
Manufacturer：ABclonal
Synonyms：CREBBP;CBP;KAT3A;RSTS;RSTS1
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | CREBBP Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CREBBP (NP_004371.2). |
| Gene ID: | 1387 |
| Swiss prot: | Q92793 |
| Molecular weight: | 260kDa/265kDa |
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