(±)-Praeruptorin A [Cas No. 73069-25-7]
Catalog No：TA-T4S1419
Manufacturer：TargetMol
Synonyms：(-)-Praeruptorin A
CAS No.：73069-25-7
Formula：C21H22O7
MWt：386.4
€65,00 – €397,00
| Name: | Praeruptorin A |
| Category: | Biochemicals |
| Description: | 1. Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction. |
| Pathway: | MAPK,PI3K/Akt/mTOR signaling |
| Target: | p38 MAPK,Akt |
| Receptor: | p38,Akt |
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