CD35/CR1 Rabbit mAb
Catalog No:AB-A3661
Manufacturer:ABclonal
Synonyms:C3BR, C4BR, CD35, KN
Applications:IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €485,00
Product Name: | CD35/CR1 Rabbit mAb |
Category: | Monoclonal Antibodies |
Description: | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008] |
Immunogen: | A synthesized peptide derived from human CD35/CR1 |
Gene ID: | 1378 |
Swiss prot: | P17927 |
Molecular weight: | 280kDa |
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