Western blot analysis of extracts of MCF7 cells, using CCM2 antibody (A6544) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
CCM2 Rabbit pAb
Catalog No:AB-A6544
Manufacturer:ABclonal
Synonyms:CCM2;C7orf22;OSM;PP10187
Applications:WB,IHC
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | CCM2 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CCM2 (NP_113631.1). |
Gene ID: | 83605 |
Swiss prot: | Q9BSQ5 |
Molecular weight: | 39kDa/42kDa/48kDa/51kDa |
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