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Western blot analysis of extracts of mouse brain, using Caspr2/Caspr2/CNTNAP2 antibody (A7466) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
Caspr2/CNTNAP2 Rabbit pAb
Catalog No：AB-A7466
Manufacturer：ABclonal
Synonyms：CNTNAP2;AUTS15;CASPR2;CDFE;NRXN4;PTHSL1
Applications：WB
Reactivity：Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | Caspr2/CNTNAP2 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human Caspr2/Caspr2/CNTNAP2 (NP_054860.1). |
| Gene ID: | 26047 |
| Swiss prot: | Q9UHC6 |
| Molecular weight: | 11kDa/148kDa |
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