Buserelin(NHN H2)
Catalog No:CP-LHRH-015B
Manufacturer:CPC Scientific
Size:25 mg
CAS No.:57982-77-1
Formula:C58H83N 17O13
MWt:1,239
€373,00
Product Name: | Buserelin(NHN H2) |
Category: | Peptides |
Three letter sequence: | Pyr-His-Trp- Ser-Tyr-D- Ser(tBu)-Leu- Arg-Pro- NHNH2 Trifluoroacet ate salt |
One letter sequence: | Pyr- HWSYs(tBu)- LRP-NHNH2 |
Description: | Buserelin is a longer acting synthetic peptide analog of the naturally occurring gonadotropin- releasing hormone (GnRH/LHRH). Substitution of glycine in position 6 by D-serine and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a significantly enhanced LHRH effect. The effects of buserelin on follicle- stimulating hormone (FSH) and luteinizing hormone (LH) release are approximately 20 to 170 times higher than those of natural LHRH. |
Literature References: | F.Roila, Biomed. Pharmacother., 43, 279 (1989) R.N.Brogden et al., Drugs, 39, 399 (1990) A.Imai et al., Am. J. Obstet. Gynecol., 182, 1142 (2000) Y.Wang et al., Eur. J. Endocrinol., 146, 447 (2002) A.Imai et al., Int. J. Oncol., 20, 987 (2002) J.Franklin et al., J. Endocrinol., 176, 275 (2003) Merck Index, 14th ed., No. 1503, (2006) |
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