BI-0115 [Cas No. 4929-23-1]
Catalog No:TA-T9108
Manufacturer:TargetMol
CAS No.:4929-23-1
Formula:C15H14ClN3O
MWt:287.747
€149,00 – €3.055,00
Name: | BI-0115 |
Category: | Biochemicals |
Description: | BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding. |
Pathway: | Metabolism |
Target: | Lipoxygenase |
Receptor: | LOX-1 |
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